Best speaker brand in general is Wilson IMO. If you are planning to go all out, grab the Alexandria X-2... best speakers I've ever heard, they even sound great out a low end source. For a good cdp, it's hard to beat Wadia's 861, and for an integrated amp I'd recommend a DIY. There are plenty of builders out there if you don't want to build your own. I don't know too much about the low-mid range speakers, but my cheap Swan M200 multimedia speakers are very good for the price..
Also I'd stay as far away from Bose as possible. They are the McDonalds of audio. They advertise a lot, everyone has heard of them, and the uninformed think they are the greatest speakers available because they are the highest priced brand available @ Best Buy/Circuit City. I have heard plenty of speakers & headphones, and Bose is very overpriced for the quality they offer. My current TV speakers are the the Bose Acousimass 6 (they came with the house, and I don't watch enough TV to warrant better speakers..) and they sound horrible. I can go on and on about the bloated one note bass, no mids and extremely peaky and non detailed highs. Plus, the build quality is the worst I've ever seen. The "cute" little cubes are just plastic cases with no dampening and cheap paper drivers. The Acoustimass sub is even worse. To read a more informed criticism, check out
http://intellexual.net/bose.html